mefi
09.03.2021, 12:35:14
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Traces of psychedelics make you feel good, but so does placebo, finds unusual ‘self-blinding’ study
People who take tiny amounts of LSD, “magic mushrooms,” and related drugs report a range of benefits, from more creativity to improved psychological well-being. But do these microdoses—typically less than 10% of the amount that causes a true psychedelic experience—actually benefit the mind?
That’s been a hard question to answer. Placebo-controlled trials are tricky to pull off, because psychedelics are so tightly regulated. Now, researchers have come up with a creative workaround: They’ve enlisted microdosing enthusiasts to hide their drugs in gel capsules and mix them up with empty capsules.
The upshot of this “self-blinding” study: Microdosing did lead to improvements in psychological well-being—but so did the placebo capsules. “The benefits are real,” says lead author Balázs Szigeti, a neuroscientist at Imperial College London. “But they are not caused by the pharmacological effects of microdosing.”
The findings, however, are “the least interesting thing about this study,” says Noah Haber, a study design specialist at Stanford University. The “very, very clever” method of self-blinding pushes the boundaries of what can be investigated using randomized placebo controls, he says.
Getting the new study off the ground wasn’t easy. Obtaining ethical approval to enroll psychedelic-taking volunteers was a “long and difficult process,” Szigeti says. And then he had to go out and find those volunteers, which he did by reaching out to microdosing communities, giving talks at psychedelic societies, and holding an “ask me anything” discussion on Reddit. Szigeti eventually garnered more than 1600 sign-ups, but once potential participants realized they’d have to procure their own psychedelics, interest ebbed, and only 246 ended up in the experiment.
This first study is like a half-time score of two-to-zero at a soccer game, Szigeti says: It’s not impossible that psychedelic microdosing might come back against the odds and show an effect, but “from what we have, it just does not look good.”
Zdroj: Cathleen O’Grady, Mar. 5, 2021 , 12:00 PM
Posted in: Brain & Behavior, doi:10.1126/science.abh3977
https://www.sciencemag.org/news/2021/03/traces-psychedelics-make-you-feel-good-so-does-placebo-finds-unusual-self-blinding?utm_campaign=news_daily_2021-03-08&et_rid=742570496&et_cid=3692290
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